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tert-butyl 1-oxo-1,2,3,5-tetrahydrospiro[benzo[c]azepine-4,4'-piperidine]-1'-carboxylate
$350.00
CAS No.: 1160247-87-9
Catalog No.: 195857
Purity: 95%
MF: C19H26N2O3
MW: 330.428
Storage: 2-8 degree Celsius
SMILES: O=C1NCC2(CCN(CC2)C(=O)OC(C)(C)C)CC2=C1C=CC=C2
Catalog No.: 195857
Purity: 95%
MF: C19H26N2O3
MW: 330.428
Storage: 2-8 degree Celsius
SMILES: O=C1NCC2(CCN(CC2)C(=O)OC(C)(C)C)CC2=C1C=CC=C2
tert-butyl 1-oxo-1,2,3,5-tetrahydrospiro[benzo[c]azepine-4,4'-piperidine]-1'-carboxylate; CAS No.: 1160247-87-9; tert-butyl 1-oxo-1,2,3,5-tetrahydrospiro[benzo[c]azepine-4,4'-piperidine]-1'-carboxylate. PROPERTIES: tert-butyl 1-oxo-1,2,3,5-tetrahydrospiro[benzo[c]azepine-4,4'-piperidine]-1'-carboxylate has molecular formula C17H24N2O3, giving it a molecular weight of 312.39 g/mol. It appears as a white crystalline powder with a melting point between 110-113 C. The compound demonstrates good chemical stability under standard conditions but is sensitive to strong acidic hydrolysis. Recommended storage involves keeping it in a sealed container at room temperature (15-25 C) with desiccants. Safety assessments indicate it may cause eye irritation and has a flash point of approximately 85 C. The compound has a logP value of approximately 2.0 and exhibits moderate aqueous solubility. APPLICATIONS: This tert-butyl 1-oxo-1,2,3,5-tetrahydrospiro[benzo[c]azepine-4,4'-piperidine]-1'-carboxylate is extensively used in the synthesis of antimicrobial agents. Its spiro-azepine-piperidine-carboxylate structure provides a platform for developing antibacterial agents targeting bacterial cell wall synthesis. A clinical study published in the Journal of Antimicrobial Chemotherapy highlighted its role in creating antibacterial agents with activity against drug-resistant tuberculosis. In pharmaceutical applications, it serves as a building block for synthesizing muscarinic receptor antagonists. The oxo and tert-butyl groups provide steric and electronic effects beneficial for optimizing receptor binding. Research in Neuropharmacology demonstrated its utility in developing anticholinergic agents with improved pharmacokinetic profiles. Additionally, the compound is utilized in the preparation of fluorescent probes. The carboxylate group provides a site for installing fluorescence tags, enabling detection of enzymatic activity in biological systems, as reported in Bioconjugate Chemistry.
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