ethyl 3-bromocyclobutane-1-carboxylate
$315.00
CAS No.: 1934754-13-8
Catalog No.: 195554
Purity: 95%
MF: C7H11BrO2
MW: 207.067
Storage: 2-8 degree Celsius
SMILES: BrC1CC(C1)C(=O)OCC
Catalog No.: 195554
Purity: 95%
MF: C7H11BrO2
MW: 207.067
Storage: 2-8 degree Celsius
SMILES: BrC1CC(C1)C(=O)OCC
ethyl 3-bromocyclobutane-1-carboxylate; CAS No.: 1934754-13-8; ethyl 3-bromocyclobutane-1-carboxylate. PROPERTIES: Ethyl 3-bromocyclobutane-1-carboxylate is a colorless to pale yellow liquid with molecular formula C7H11BrO2. It exhibits a boiling point around 115-120 C at 760 mmHg and moderate thermal stability. The compound shows good solubility in ethyl acetate and moderate solubility in methylene chloride. Recommended storage conditions include maintaining temperatures below 30 C in sealed containers. Safety considerations involve using powder-free nitride gloves during handling to prevent skin absorption and ensuring proper ventilation to avoid inhalation of vapors. APPLICATIONS: This brominated cyclobutane ester serves as a key intermediate in the synthesis of cyclooxygenase inhibitors for anti-inflammatory applications, where the ethyl 3-bromocyclobutane-1-carboxylate group provides steric hindrance conducive to enzyme binding (Journal of Medicinal Chemistry). In organic synthesis, the compound is used as a building block for constructing medium-sized carbocycles through ring-expansion reactions (Angewandte Chemie International Edition). Furthermore, its ester functionality enables hydrolysis reactions for the preparation of corresponding carboxylic acids used in bioactive molecule development (Bioorganic & Medicinal Chemistry Letters).
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