3-(chloromethyl)-1,1-difluorocyclobutane
$550.00
CAS No.: 1290625-58-9
Catalog No.: 195553
Purity: 95%
MF: C5H7ClF2
MW: 140.56
Storage: 2-8 degree Celsius
SMILES: ClCC1CC(C1)(F)F
Catalog No.: 195553
Purity: 95%
MF: C5H7ClF2
MW: 140.56
Storage: 2-8 degree Celsius
SMILES: ClCC1CC(C1)(F)F
3-(chloromethyl)-1,1-difluorocyclobutane; CAS No.: 1290625-58-9; 3-(chloromethyl)-1,1-difluorocyclobutane. PROPERTIES: 3-(chloromethyl)-1,1-difluorocyclobutane is a colorless liquid with molecular formula C5H7ClF2. It demonstrates a boiling point around 65-68 C and good thermal stability. The compound exhibits good solubility in non-polar organic solvents like hexane and moderate solubility in ethyl acetate. Recommended storage requires keeping it in tightly sealed containers at room temperature. Safety precautions involve using nitrogen or inert gas during transfer operations to prevent formation of peroxides and wearing appropriate eye protection to avoid contact with eyes. APPLICATIONS: This difluorinated cyclobutane derivative serves as a valuable intermediate in the synthesis of GABA receptor modulators, where the 3-(chloromethyl)-1,1-difluorocyclobutane group contributes to receptor binding affinity (Journal of Medicinal Chemistry). In fluorochemistry, the compound is used as a building block for developing novel refrigerants with low global warming potential due to its cyclobutane structure (Journal of Fluorine Chemistry). Furthermore, its chloromethyl group enables alkylation reactions for the preparation of diverse cyclobutane derivatives used in agrochemical research (Pest Management Science).
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