3,3-difluoro-1-methylcyclobutan-1-amine hydrochloride
$550.00
CAS No.: 1523606-39-4
Catalog No.: 200394
Purity: 95%
MF: C5H10ClF2N
MW: 157.591
Storage: 2-8 degree Celsius
SMILES: Cl.FC1(CC(C1)(N)C)F
Catalog No.: 200394
Purity: 95%
MF: C5H10ClF2N
MW: 157.591
Storage: 2-8 degree Celsius
SMILES: Cl.FC1(CC(C1)(N)C)F
CAS NO.: 1523606-39-4;3,3-difluoro-1-methylcyclobutan-1-amine hydrochloride. PROPERTIES: This difluorinated amine salt appears as white hygroscopic powder with molecular weight approximately 165.6 g/mol (free base), combining cyclobutane ring strain with methyl and amine groups. The 3,3-difluoro-1-methylcyclobutan-1-amine hydrochloride exhibits good solubility in water and lower alcohols but limited miscibility in non-polar media. Stability characterization reveals tendency to form hydrates above 40% relative humidity, mandating storage at 2-8 degree Celsius in sealed polyethylene containers. Handlers should employ deliquescence-resistant tools and maintain environmental humidity below 30%. Skin contact may cause chemical burns in presence of moisture. Inhalation may induce bronchial hyperreactivity; treatment includes anticholinergic inhalers. Eye exposure requires extended rinsing and possible corticosteroid application. Waste should be neutralized with sodium bicarbonate prior to disposal. APPLICATIONS: The 3,3-difluoro-1-methylcyclobutan-1-amine hydrochloride serves as a key intermediate in the synthesis of glycine receptor antagonists and GABA transporter inhibitors. Its difluorocyclobutane framework provides conformational restriction that enhances receptor binding affinity. The compound functions as a building block for creating cyclobutane-containing AMPA potentiators. Additionally, it undergoes reductive amination for constructing tertiary amines with defined stereochemistry. Research teams employ it as a starting material for creating cyclobutane-based organocatalysts with enhanced enantioselectivity. In materials science, its amine group enables formation of coordination polymers for selective gas adsorption.
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