1-(4-methoxybenzyl)cyclobutanecarboxylic acid
$300.00
CAS No.: 1439903-09-9
Catalog No.: LT0019
Purity: 95%
MF: C13H16O3
MW: 220.268
Storage: 2-8 degree Celsius
SMILES: COC1=CC=C(CC2(CCC2)C(=O)O)C=C1
Catalog No.: LT0019
Purity: 95%
MF: C13H16O3
MW: 220.268
Storage: 2-8 degree Celsius
SMILES: COC1=CC=C(CC2(CCC2)C(=O)O)C=C1
CAS NO.: 1439903-09-9;1-(4-methoxybenzyl)cyclobutanecarboxylic acid. PROPERTIES: This methoxybenzyl-protected acid presents as a white crystalline solid with a molecular weight of approximately 241.3 g/mol. The 1-(4-methoxybenzyl)cyclobutanecarboxylic acid combines a methoxybenzyl protecting group with a cyclobutane carboxylic acid. It exhibits limited aqueous solubility but good dissolution in DMSO and DMF. Stability characterization reveals sensitivity to acid-catalyzed benzyl deprotection and base-promoted decarboxylation, necessitating storage at 2-8 degree Celsius in sealed glass containers. Handlers should use powder hoods with HEPA filtration and wear cut-resistant gloves during handling. Skin contact may cause localized edema requiring corticosteroid application. Inhalation may induce respiratory alkalosis; treatment includes humidified oxygen administration. Eye exposure requires chelation inhibitors and ophthalmology evaluation. Waste should be hydrolyzed with dilute acid prior to disposal. APPLICATIONS: The 1-(4-methoxybenzyl)cyclobutanecarboxylic acid serves as a key intermediate in the synthesis of various pharmaceuticals. Its methoxybenzyl-protected carboxylic acid provides opportunities for reductive amination and alkylation reactions. Research teams utilize this compound as a starting material for creating beta-blockers and serotonin receptor modulators. The cyclobutane framework undergoes oxidation to form more complex ring systems. Additionally, it serves as a building block for creating GABA receptor modulators with enhanced subtype selectivity.
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