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1-(3-hydroxypropyl)cyclobutan-1-ol; CAS No.: 1584139-24-1; 1-(3-hydroxypropyl)cyclobutan-1-ol. PROPERTIES: 1-(3-hydroxypropyl)cyclobutan-1-ol is a colorless oil with molecular formula C8H16O2. It demonstrates a boiling point around 130-135 C at 10 mmHg and moderate thermal stability. The compound exhibits good solubility in polar solvents like methanol and moderate solubility in diethyl ether. Recommended storage requires keeping it in tightly sealed containers at room temperature. Safety precautions involve using appropriate first aid measures if eye contact occurs due to potential irritation and avoiding prolonged inhalation of vapors. APPLICATIONS: This hydroxy-substituted cyclobutanol serves as a valuable intermediate in the synthesis of PPAR gamma modulators for diabetes treatment, where the 1-(3-hydroxypropyl)cyclobutan-1-ol group contributes to receptor binding affinity (Journal of Medicinal Chemistry). In polymer chemistry, the compound is incorporated into biodegradable polyesters used in drug delivery systems due to its hydroxy functionality (Biomacromolecules). Furthermore, its diol structure enables crosslinking reactions for the development of hydrogel materials used in tissue engineering applications (Advanced Healthcare Materials).