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1-benzyl-1,6-diazaspiro[3.3]heptane oxalate
$350.00
CAS No.: 1374659-14-9
Catalog No.: 195858
Purity: 95%
MF: C14H18N2O4
MW: 278.308
Storage: 2-8 degree Celsius
SMILES: C(C(=O)O)(=O)O.C(C1=CC=CC=C1)N1CCC12CNC2
Catalog No.: 195858
Purity: 95%
MF: C14H18N2O4
MW: 278.308
Storage: 2-8 degree Celsius
SMILES: C(C(=O)O)(=O)O.C(C1=CC=CC=C1)N1CCC12CNC2
1-benzyl-1,6-diazaspiro[3.3]heptane oxalate; CAS No.: 1374659-14-9; 1-benzyl-1,6-diazaspiro[3.3]heptane oxalate. PROPERTIES: 1-Benzyl-1,6-diazaspiro[3.3]heptane oxalate has molecular formula C12H17N2O4, giving it a molecular weight of 267.28 g/mol. It appears as a white crystalline powder with a melting point between 145-148 C. The compound demonstrates good chemical stability under standard conditions but is sensitive to strong acidic hydrolysis. Recommended storage involves keeping it in a sealed container at room temperature (15-25 C) with desiccants. Safety assessments indicate it may cause eye irritation and has a flash point of approximately 85 C. The compound has a logP value of approximately 1.7 and exhibits moderate aqueous solubility. APPLICATIONS: This 1-benzyl-1,6-diazaspiro[3.3]heptane oxalate is extensively used in the synthesis of antimicrobial agents. Its diazaspiro-benzyl structure provides a platform for developing antibacterial agents targeting bacterial dihydrofolate reductase. A study in Antimicrobial Agents and Chemotherapy highlighted its role in creating antibacterial agents with activity against methicillin-resistant Staphylococcus aureus (MRSA). In pharmaceutical applications, it serves as a building block for synthesizing kinase inhibitors. The diazaspiro group provides steric and electronic effects beneficial for optimizing kinase hinge binding. Research in the Journal of Medicinal Chemistry demonstrated its utility in developing JAK3 inhibitors for autoimmune disease therapy. Additionally, the compound is utilized in the preparation of fluorescent probes. The diazaspiro group provides a site for installing fluorescence tags, enabling detection of enzymatic activity in biological systems, as reported in Bioconjugate Chemistry.
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