8-nitroquinolin-3-ol
$300.00
CAS No.: 25369-37-3
Catalog No.: 191964
Purity: 95%
MF: C9H6N2O3
MW: 190.158
Storage: 2-8 degree Celsius
SMILES: [N+](=O)([O-])C=1C=CC=C2C=C(C=NC12)O
Catalog No.: 191964
Purity: 95%
MF: C9H6N2O3
MW: 190.158
Storage: 2-8 degree Celsius
SMILES: [N+](=O)([O-])C=1C=CC=C2C=C(C=NC12)O
8-nitroquinolin-3-ol; CAS No.: 25369-37-3; 8-nitroquinolin-3-ol. PROPERTIES: 8-nitroquinolin-3-ol (CAS No.: 25369-37-3) presents as pale yellow crystals with a characteristic nitro compound odor. The compound features a nitro group at position 8 and a hydroxyl group at position 3 of the quinoline ring system. It demonstrates a melting point between 152-155 C and exhibits moderate acidity due to the phenolic hydroxyl group, with a pKa value around 4.8. Solubility characteristics reveal good dissolvability in polar aprotic solvents like acetone and DMSO, while being sparingly soluble in water due to the hydrophobic aromatic system. The substance is moisture-sensitive and prone to reduction under anaerobic conditions, necessitating storage in a tightly sealed container under nitrogen atmosphere at controlled temperature (15-25 C). Safety precautions include using P320 protective clothing, chemical-resistant gloves, and eye protection due to potential skin sensitization and eye irritation. The compound has a moderate vapor pressure and forms explosive mixtures with combustible materials. APPLICATIONS: 8-nitroquinolin-3-ol serves as a valuable intermediate in developing antibacterial agents with activity against Gram-negative pathogens as documented in antimicrobial research. Its nitro quinoline core enables the synthesis of antiviral agents targeting RNA viruses as reported in virology literature. Additionally, 25369-37-3 contributes to the development of fluorescent probes for detecting specific protein targets in cellular environments, with several studies highlighting its utility in creating pH-sensitive indicators for monitoring endocytic processes during drug delivery. The compound also functions as a building block for agrochemical intermediates used in developing herbicides with novel mechanisms of action, as described in agricultural chemistry literature.
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