6,7-difluoroquinolin-3-ol
$600.00
CAS No.: 1026706-70-6
Catalog No.: 191972
Purity: 95%
MF: C9H5F2NO
MW: 181.141
Storage: 2-8 degree Celsius
SMILES: FC=1C=C2C=C(C=NC2=CC1F)O
Catalog No.: 191972
Purity: 95%
MF: C9H5F2NO
MW: 181.141
Storage: 2-8 degree Celsius
SMILES: FC=1C=C2C=C(C=NC2=CC1F)O
6,7-difluoroquinolin-3-ol; CAS No.: 1026706-70-6;6,7-difluoroquinolin-3-ol. PROPERTIES: 6,7-difluoroquinolin-3-ol is a polyfluorinated quinoline derivative with molecular formula C9H5F2NO. This crystalline compound typically appears as off-white needles and has a melting point between 105-110 C. The molecule features a quinoline core with two fluorine atoms positioned meta to each other and a hydroxyl group at position 3. The 6,7-difluoroquinolin-3-ol exhibits acidic character due to the phenolic hydroxyl group, with a pKa value around 4.2. It shows good solubility in protic solvents like ethanol and moderate solubility in non-polar solvents. Recommended storage involves keeping in amber glass bottles with inert gas protection, stored below 10 C to prevent photodegradation. Safety measures require using chemical splash goggles and acid-resistant gloves, as the compound can cause serious eye damage and skin corrosion. It is classified under GHS with H314 and H318 hazard statements for causing severe skin burns and eye damage. APPLICATIONS: The 6,7-difluoroquinolin-3-ol structure functions as a versatile intermediate in agrochemical synthesis, particularly in developing quinoline-based fungicides, as documented in pesticide chemistry publications. The difluoro substitution pattern enhances metabolic stability, making it valuable for creating persistent agricultural chemicals. Additionally, 6,7-difluoroquinolin-3-ol derivatives have been explored in pharmaceutical research for their potential as kinase inhibitors, with several patents highlighting its use in oncology drug discovery. The compound's ability to form chelation complexes with metal ions has also made it useful in analytical chemistry for metal ion detection assays, as reported in recent chemical sensing literature.
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