8-fluoroisoquinolin-5-amine
$300.00
CAS No.: 608515-47-5
Catalog No.: 191946
Purity: 95%
MF: C9H7FN2
MW: 162.167
Storage: 2-8 degree Celsius
SMILES: FC1=CC=C(C=2C=CN=CC12)N
Catalog No.: 191946
Purity: 95%
MF: C9H7FN2
MW: 162.167
Storage: 2-8 degree Celsius
SMILES: FC1=CC=C(C=2C=CN=CC12)N
8-fluoroisoquinolin-5-amine; CAS No.: 608515-47-5; 8-fluoroisoquinolin-5-amine. PROPERTIES: 8-fluoroisoquinolin-5-amine (CAS No.: 608515-47-5) manifests as a pale yellow crystalline powder with characteristic isoquinoline ring system bearing a fluorine substituent at position 8 and an amino group at position 5. The compound exhibits a melting point between 182-185 C and demonstrates moderate basicity due to the amine functionality, with a pKa value around 5.2 for the protonated form. Its solubility profile shows good dissolvability in polar aprotic solvents like acetone and ethyl acetate, while being sparingly soluble in water. The substance is hygroscopic and prone to oxidation upon prolonged exposure to air, requiring storage in tightly sealed amber containers under nitrogen atmosphere at 2-8 C. Safety precautions include using P290 respiratory protection, chemical-resistant gloves, and eye protection due to its potential to cause skin sensitization and respiratory tract irritation. The compound presents a moderate fire hazard with a flash point above 70 C. APPLICATIONS: 8-fluoroisoquinolin-5-amine has gained prominence in oncology research as a building block for kinase inhibitors targeting FLT3 and ABL kinases as reported in cancer therapeutics literature. Its fluorinated isoquinoline scaffold enables bioisosteric modifications in drug discovery, facilitating improved metabolic stability of lead compounds. Furthermore, 608515-47-5 serves as a precursor in developing fluorescent probes for detecting reactive oxygen species in biological systems, with several studies highlighting its utility in monitoring oxidative stress in cellular environments through fluorescence intensity changes.
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