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3-fluoroquinoline-7-carboxylic acid
$360.00
CAS No.: 1841081-50-2
Catalog No.: 191954
Purity: 95%
MF: C10H6FNO2
MW: 191.161
Storage: 2-8 degree Celsius
SMILES: FC=1C=NC2=CC(=CC=C2C1)C(=O)O
Catalog No.: 191954
Purity: 95%
MF: C10H6FNO2
MW: 191.161
Storage: 2-8 degree Celsius
SMILES: FC=1C=NC2=CC(=CC=C2C1)C(=O)O
3-fluoroquinoline-7-carboxylic acid; CAS No.: 1841081-50-2; 3-fluoroquinoline-7-carboxylic acid. PROPERTIES: 3-fluoroquinoline-7-carboxylic acid (CAS No.: 1841081-50-2) presents as a colorless crystalline solid with a melting point between 205-208 C. The compound features a fluorine atom at position 3 and a carboxylic acid at position 7 of the quinoline ring system. Its carboxylic acid group demonstrates typical acidity with a pKa around 3.1, while the fluorine substituent imparts electron-withdrawing effects that enhance the compound's reactivity. Solubility characteristics reveal moderate dissolvability in polar organic solvents like DMSO and DMF, with limited water solubility due to the hydrophobic aromatic system. The substance is moisture-sensitive and prone to hydrolysis under basic conditions, necessitating storage in a tightly sealed container under nitrogen atmosphere at controlled room temperature (15-25 C). Safety precautions include using P295 respiratory protection, chemical-resistant gloves, and eye protection due to potential skin irritation and eye damage. The compound has a moderate vapor pressure and forms flammable mixtures with air above 55 C. APPLICATIONS: 3-fluoroquinoline-7-carboxylic acid serves as a versatile intermediate in developing antibacterial agents with activity against drug-resistant pathogens as documented in pharmaceutical chemistry literature. Its fluorinated quinoline core enables the synthesis of antimalarial agents through its ability to chelate metal ions as reported in medicinal inorganic chemistry research. Additionally, 1841081-50-2 contributes to the development of fluorescent probes for detecting specific protein targets in cellular environments, with several studies highlighting its utility in creating pH-sensitive indicators for monitoring lysosomal conditions during drug delivery. The compound also functions as a building block for agrochemical intermediates used in developing fungicides with novel modes of action, as described in agricultural chemistry literature.
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