5-chloropyrimidin-4-ol
$360.00
CAS No.: 4349-08-0
Catalog No.: 196443
Purity: 95%
MF: C4H3ClN2O
MW: 130.534
Storage: 2-8 degree Celsius
SMILES: ClC=1C(=NC=NC1)O
Catalog No.: 196443
Purity: 95%
MF: C4H3ClN2O
MW: 130.534
Storage: 2-8 degree Celsius
SMILES: ClC=1C(=NC=NC1)O
5-chloropyrimidin-4-ol; CAS No.: 4349-08-0; 5-chloropyrimidin-4-ol. PROPERTIES: 5-chloropyrimidin-4-ol has molecular formula C4H3ClN2O with molecular weight approximately 134.54 g/mol. It typically forms colorless crystals with a reported melting point of 128-131 C. The compound demonstrates moderate solubility in polar organic solvents and limited water solubility. Proper storage requires a tightly sealed container at room temperature away from moisture and light. Safety considerations include avoiding release to the environment and using personal protective equipment during handling. The chloro substituent may release toxic fumes when exposed to heat. In case of skin contact, thorough washing with soap and water is recommended. APPLICATIONS: 5-chloropyrimidin-4-ol functions as a versatile intermediate in pharmaceutical synthesis. Its chloro substituent enables participation in nucleophilic aromatic substitution reactions. In medicinal chemistry, it has been used to develop novel anticancer agents targeting kinases, as documented in oncology-focused pharmaceutical research journals. The pyrimidinol structure allows for hydrogen bonding interactions critical for biological activity. Additionally, this compound serves as a building block for specialty chemicals, with applications reported in fine chemical literature focusing on heterocyclic compounds for material science.
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