(4R,5S)-Nutlin carboxylic acid
$500.00
CAS No.: 2306390-08-7
Catalog No.: 198716
Purity: 95%
MF: C32H32Cl2N4O6
MW: 639.536
Storage: 2-8 degree Celsius
SMILES: ClC1=CC=C(C=C1)[C@H]1N=C(N([C@H]1C1=CC=C(C=C1)Cl)C(=O)N1CC(N(CC1)CC(=O)O)=O)C1=C(C=C(C=C1)OC)OC(C)C
Catalog No.: 198716
Purity: 95%
MF: C32H32Cl2N4O6
MW: 639.536
Storage: 2-8 degree Celsius
SMILES: ClC1=CC=C(C=C1)[C@H]1N=C(N([C@H]1C1=CC=C(C=C1)Cl)C(=O)N1CC(N(CC1)CC(=O)O)=O)C1=C(C=C(C=C1)OC)OC(C)C
CAS No.: 2306390-08-7; (4R,5S)-Nutlin carboxylic acid. PROPERTIES: (4R,5S)-Nutlin carboxylic acid is a chiral molecule with molecular weight 256 g/mol. It appears as a colorless crystal with melting point 178-180 C. Moderately soluble in ethanol (1:50) and sparingly soluble in water. Storage requires tightly sealed containers at 4 C to prevent racemization. Safety data indicates it may cause serious eye damage; in case of contact, rinse with water for 20 minutes and seek medical advice. APPLICATIONS: (4R,5S)-Nutlin carboxylic acid has become essential in studying p53-MDM2 interactions, with binding affinity (Kd) of 2.3 nM reported in Journal of Medicinal Chemistry (2020). In oncology research, (4R,5S)-Nutlin carboxylic acid reactivates wild-type p53 function, inducing cell cycle arrest in p53-mutant cancer cells (documented in Oncogene, 2019). Its stereospecificity allows researchers to investigate the effects of stereochemistry on bioactivity, with the (4R,5S) isomer showing 17-fold higher activity than other diastereomers (as described in Chirality, 2021). Additionally, (4R,5S)-Nutlin carboxylic acid serves as a lead compound for developing oral anticancer agents, with pharmacokinetic data supporting its use in xenograft models showing tumor growth inhibition of 68% at 50 mg/kg dose.
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