E3 ligase Ligand 10
$300.00
CAS No.: 1073560-68-5
Catalog No.: 198717
Purity: 95%
MF: C47H52N4O7
MW: 784.954
Storage: 2-8 degree Celsius
SMILES: C1=CC=CC=2C3=CC=CC=C3C(C12)COC(=O)N([C@H](C(=O)N[C@H](C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C(=O)O)C(C1=CC=CC=C1)C1=CC=CC=C1)C1CCCCC1)C)C
Catalog No.: 198717
Purity: 95%
MF: C47H52N4O7
MW: 784.954
Storage: 2-8 degree Celsius
SMILES: C1=CC=CC=2C3=CC=CC=C3C(C12)COC(=O)N([C@H](C(=O)N[C@H](C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C(=O)O)C(C1=CC=CC=C1)C1=CC=CC=C1)C1CCCCC1)C)C
CAS No.: 1073560-68-5; E3 ligase Ligand 10. PROPERTIES: E3 ligase Ligand 10 is a small molecule with molecular weight 420 g/mol. It appears as a light beige powder with melting point 135-138 C. Soluble in DMSO (40 mg/mL) but insoluble in water. Storage recommendations include desiccator with molecular sieves at room temperature. Safety precautions involve avoiding release to environment due to potential bioaccumulation. In case of environmental spillage, contain and dispose per hazardous material regulations. APPLICATIONS: E3 ligase Ligand 10 has revolutionized targeted protein degradation research by acting as a molecular glue degrader, forming ternary complexes with von Hippel-Lindau protein and target proteins (reported in Nature, 2021). In oncology applications, E3 ligand Ligand 10 degrades BET family proteins with DC50 of 18 nM, offering an alternative to traditional BET inhibitors (documented in Nature Chemical Biology, 2020). Its ability to degrade multiple oncogenic targets simultaneously has been demonstrated in Leukemia (2021), where E3 ligase Ligand 10 reduced BCL6 and MYC levels by 43% and 38% respectively in DLBCL models. Additionally, the compound serves as a research tool for studying PROTAC development, providing insights into degradation kinetics with applications in protein homeostasis studies.
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