4-chloro-2-fluoroanisole
$300.00
CAS No.: 452-09-5
Catalog No.: 194055
Purity: 95%
MF: C7H6ClFO
MW: 160.575
Storage: 2-8 degree Celsius
SMILES: ClC1=CC(=C(C=C1)OC)F
Catalog No.: 194055
Purity: 95%
MF: C7H6ClFO
MW: 160.575
Storage: 2-8 degree Celsius
SMILES: ClC1=CC(=C(C=C1)OC)F
4-chloro-2-fluoroanisole; CAS No.: 452-09-5; 4-chloro-2-fluoroanisole. PROPERTIES: 4-chloro-2-fluoroanisole is a colorless to pale yellow liquid with a molecular weight of 165.6 g/mol. It has a boiling point around 165-167 C at 760 mmHg and exhibits low water solubility while being miscible with common organic solvents such as dichloromethane, ethyl acetate, and tetrahydrofuran. The compound contains a chlorine substituent, fluorine substituent, and methoxy group, which impart significant chemical stability and distinct reactivity patterns. Proper storage requires keeping the compound in a tightly sealed container at temperatures below 20 C, protected from light and moisture. Safety precautions include using protective gloves, eye protection, and ensuring adequate ventilation during handling. The compound may cause serious eye damage and skin irritation, and appropriate first aid measures should be followed in case of exposure. APPLICATIONS: 4-chloro-2-fluoroanisole serves as a versatile building block in organic synthesis, particularly in the preparation of various pharmaceuticals and specialty chemicals. Its unique substitution pattern makes it suitable for cross-coupling reactions, enabling the synthesis of complex aromatic systems for medicinal applications. In the field of medicinal chemistry, it functions as a precursor to certain antidepressant and antipsychotic drugs, as described in psychopharmacology literature. The chlorine and fluorine substituents provide convenient handles for further functionalization, such as in Suzuki-Miyaura couplings. Additionally, the compound is utilized in the production of liquid crystalline materials, where the methoxy group contributes to desired physical properties. In materials science, it serves as a building block for certain types of conductive polymers and sensors, as reported in recent advances in organic materials science. The strategic positioning of the chlorine, fluorine, and methoxy groups allows for selective derivatization, expanding its utility in organic synthesis.
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