4-bromo-3-methoxyphenylacetonitrile
$250.00
CAS No.: 113081-50-8
Catalog No.: 194047
Purity: 95%
MF: C9H8BrNO
MW: 226.073
Storage: 2-8 degree Celsius
SMILES: BrC1=C(C=C(C=C1)CC#N)OC
Catalog No.: 194047
Purity: 95%
MF: C9H8BrNO
MW: 226.073
Storage: 2-8 degree Celsius
SMILES: BrC1=C(C=C(C=C1)CC#N)OC
4-bromo-3-methoxyphenylacetonitrile; CAS No.: 113081-50-8; 4-bromo-3-methoxyphenylacetonitrile. PROPERTIES: 4-bromo-3-methoxyphenylacetonitrile is a crystalline solid with a molecular weight of 237.1 g/mol. It typically exhibits a melting point in the range of 65-68 C and limited water solubility, though it dissolves readily in organic solvents such as methanol, ethanol, and dichloromethane. The compound contains reactive functional groups including a nitrile group, bromine substituent, and methoxy group, which contribute to its chemical versatility. For optimal storage, it should be kept in a tightly sealed container at temperatures below 20 C, preferably under inert atmosphere to prevent potential degradation. Safety considerations include wearing appropriate protective clothing, gloves, and eye/face protection to minimize exposure risk. The compound may cause eye irritation and skin irritation, and in case of accidental ingestion, immediate medical attention is advised. APPLICATIONS: 4-bromo-3-methoxyphenylacetonitrile serves as a valuable intermediate in the synthesis of various pharmaceuticals, particularly in the development of targeted kinase inhibitors for cancer therapy. Its unique substitution pattern allows for selective derivatization, making it suitable for constructing bioactive scaffolds, as reported in oncology research publications. In materials science, the compound functions as a building block for certain types of conductive polymers, where the electron-donating methoxy group and electron-withdrawing bromine substituent create a balanced electronic environment. Additionally, it is utilized in the preparation of specialty dyes and pigments, particularly those requiring thermal stability. Through chemical modification of the nitrile group, it can be converted into various amides, amines, or carboxylic acids, expanding its application scope in organic synthesis. The bromine substituent provides a convenient handle for further functionalization, such as in cross-coupling reactions.
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