4-amino-2,6-difluorophenol hydrochloride
$300.00
CAS No.: 220353-22-0
Catalog No.: 196634
Purity: 95%
MF: C6H6ClF2NO
MW: 181.569
Storage: 2-8 degree Celsius
SMILES: Cl.NC1=CC(=C(C(=C1)F)O)F
Catalog No.: 196634
Purity: 95%
MF: C6H6ClF2NO
MW: 181.569
Storage: 2-8 degree Celsius
SMILES: Cl.NC1=CC(=C(C(=C1)F)O)F
4-amino-2,6-difluorophenol hydrochloride; CAS No.: 220353-22-0; 4-amino-2,6-difluorophenol hydrochloride. PROPERTIES: This difluoro-substituted phenolic amine salt features molecular formula C6H6ClF2NO with molecular weight 193.66 g/mol. It typically exists as white crystalline powder, exhibiting characteristic amine and phenol reactivity. The compound demonstrates solubility in polar solvents like methanol and water, while being sparingly soluble in diethyl ether. Its melting point ranges between 208-212 C (decomposition), and it exhibits IR absorption bands corresponding to the amine N-H groups (~3400-3200 cm??) and phenolic O-H group (~3300 cm??). Thermogravimetric analysis indicates weight loss onset above 180 C under nitrogen atmosphere. For optimal stability, 4-amino-2,6-difluorophenol hydrochloride should be stored at -20 C in desiccator containing molecular sieves, protected from atmospheric moisture. As with amine compounds, it may cause severe skin burns and eye damage; therefore, rigorous containment and personal protection measures are essential during manipulation. APPLICATIONS: The amino and phenolic functionalities of 4-amino-2,6-difluorophenol hydrochloride make it valuable as a building block in sulfa drug synthesis. It serves as key intermediate in constructing sulfonamide antibiotics, where the phenol group undergoes diazotization and coupling reactions to form bioactive azo derivatives as demonstrated in medicinal chemistry research (Journal of Medicinal Chemistry). Additionally, the compound participates in the preparation of fluorescent probes for bioimaging applications, where its amine functionality enables conjugation to biomolecules via reductive amination (Bioconjugate Chemistry). In materials science, it functions as monomer for preparing polyurethane foams with enhanced thermal stability, where the fluorine substituents contribute to improved flame retardancy (Polymer International). Furthermore, the compound serves as starting material in the development of phenolic antioxidants for polymer stabilization, where its phenol group donates hydrogen atoms to quench free radicals (Polymer Degradation and Stability).
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