2-(4-fluorophenyl)-2-oxoacetaldehyde hydrate
$300.00
CAS No.: 447-43-8
Catalog No.: 196632
Purity: 95%
MF: C8H7FO3
MW: 170.139
Storage: 2-8 degree Celsius
SMILES: O.FC1=CC=C(C=C1)C(C=O)=O
Catalog No.: 196632
Purity: 95%
MF: C8H7FO3
MW: 170.139
Storage: 2-8 degree Celsius
SMILES: O.FC1=CC=C(C=C1)C(C=O)=O
2-(4-fluorophenyl)-2-oxoacetaldehyde hydrate; CAS No.: 447-43-8; 2-(4-fluorophenyl)-2-oxoacetaldehyde hydrate. PROPERTIES: This fluoro-substituted ϫ-ketoaldehyde possesses molecular formula C8H7FO3 with molecular weight 169.14 g/mol. It generally appears as white to off-white crystalline powder, exhibiting characteristic aldehyde and ketone reactivity. The compound demonstrates solubility in polar aprotic solvents like DMF and DMSO, while being sparingly soluble in methanol. Its melting point ranges between 120-124 C, and it exhibits IR absorption bands corresponding to the aldehyde group (~2800-2600 cm??) and ketone group (~1700 cm??). Thermogravimetric analysis reveals decomposition onset above 180 C under nitrogen atmosphere. For optimal stability, 2-(4-fluorophenyl)-2-oxoacetaldehyde hydrate should be stored at -20 C in desiccator containing molecular sieves, protected from atmospheric moisture. As with aldehyde compounds, it may cause severe skin burns and eye damage; therefore, rigorous containment and personal protection measures are essential during manipulation. APPLICATIONS: As a bifunctional carbonyl compound, 2-(4-fluorophenyl)-2-oxoacetaldehyde hydrate is particularly effective as building block in heterocycle synthesis. It serves as key intermediate in the preparation of oxindole derivatives, which are prevalent in pharmaceutical agents targeting kinases and proteases as demonstrated in medicinal chemistry research (Heterocycles). Additionally, the compound participates in the synthesis of fluorescent probes for bioimaging applications, where its aldehyde functionality enables conjugation to primary amines in biomolecules via Schiff base formation (Bioconjugate Chemistry). In materials science, it functions as monomer for preparing polyketone polymers with enhanced thermal stability, where the fluorine atom contributes to improved flame retardancy (Polymer Chemistry). Furthermore, the compound serves as starting material in the development of aldehyde-based crosslinking agents for protein immobilization, where its dual carbonyl groups enable formation of covalent bonds with amino acid side chains (ACS Applied Materials & Interfaces).
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