4,6-dihydroxypyrimidine-5-carbaldehyde
$200.00
CAS No.: 14256-99-6
Catalog No.: 196423
Purity: 95%
MF: C5H4N2O3
MW: 140.098
Storage: 2-8 degree Celsius
SMILES: OC1=NC=NC(=C1C=O)O
Catalog No.: 196423
Purity: 95%
MF: C5H4N2O3
MW: 140.098
Storage: 2-8 degree Celsius
SMILES: OC1=NC=NC(=C1C=O)O
4,6-dihydroxypyrimidine-5-carbaldehyde; CAS No.: 14256-99-6; 4,6-dihydroxypyrimidine-5-carbaldehyde. PROPERTIES: This compound presents a 4,6-dihydroxypyrimidine-5-carbaldehyde structure, combining two hydroxyl groups and an aldehyde group on the pyrimidine framework. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 168.1 g/mol (C4H4N2O3). The melting point ranges between 150-155 C, and it exhibits moderate solubility in common organic solvents like ethanol, methanol, and DMSO while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 4,6-Dihydroxypyrimidine-5-carbaldehyde serves as a specialized intermediate in pharmaceutical research. Its 4,6-dihydroxypyrimidine-5-carbaldehyde structure enables diverse reactivity patterns, including nucleophilic addition at the aldehyde carbonyl and hydrogen bonding interactions through the hydroxyl groups. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The aldehyde group can be readily modified through reductive amination or cyanosilylation. This compound also functions as a building block in the synthesis of fluorescent dyes and bioconjugation reagents. Academic studies utilize it as a model system in Medicinal Chemistry journals, focusing on optimizing the 4,6-dihydroxypyrimidine-5-carbaldehyde scaffold for improved biological activity and target engagement.
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