4,6-diiodo-2-methylpyrimidine
$200.00
CAS No.: 66298-49-5
Catalog No.: 196424
Purity: 95%
MF: C5H4I2N2
MW: 345.909
Storage: 2-8 degree Celsius
SMILES: IC1=NC(=NC(=C1)I)C
Catalog No.: 196424
Purity: 95%
MF: C5H4I2N2
MW: 345.909
Storage: 2-8 degree Celsius
SMILES: IC1=NC(=NC(=C1)I)C
4,6-diiodo-2-methylpyrimidine; CAS No.: 66298-49-5; 4,6-diiodo-2-methylpyrimidine. PROPERTIES: This compound features a 4,6-diiodo-2-methylpyrimidine structure, combining two iodine atoms and a methyl group on the pyrimidine framework. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 386.0 g/mol (C5H4I2N2). The melting point ranges between 160-165 C, and it exhibits moderate solubility in common organic solvents like DMSO and DMF while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 4,6-Diiodo-2-methylpyrimidine serves as a versatile intermediate in pharmaceutical and chemical synthesis. Its 4,6-diiodo-2-methylpyrimidine structure allows for participation in various reactions, including palladium-catalyzed cross-coupling reactions at the iodine positions and nucleophilic substitution at the pyrimidine ring. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The diiodo substituents provide handles for introducing aryl, vinyl, or heterocyclic substituents. This compound also functions as a building block in the synthesis of fluorescent dyes and bioconjugation reagents. Academic studies employ it as a model compound in Organic Chemistry journals, focusing on the development of novel diiodopyrimidine derivatives based on the 4,6-diiodo-2-methylpyrimidine scaffold.
Reviews
Write Your Own Review