4,5,6-trichloropyrimidine
$300.00
CAS No.: 1780-27-4
Catalog No.: 196422
Purity: 95%
MF: C4HCl3N2
MW: 183.425
Storage: 2-8 degree Celsius
SMILES: ClC1=NC=NC(=C1Cl)Cl
Catalog No.: 196422
Purity: 95%
MF: C4HCl3N2
MW: 183.425
Storage: 2-8 degree Celsius
SMILES: ClC1=NC=NC(=C1Cl)Cl
4,5,6-trichloropyrimidine; CAS No.: 1780-27-4; 4,5,6-trichloropyrimidine. PROPERTIES: This compound features a 4,5,6-trichloropyrimidine structure, combining three chlorine atoms on the pyrimidine framework. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 193.0 g/mol (C3HCl3N2). The melting point ranges between 90-95 C, and it exhibits moderate solubility in common organic solvents like DMSO and DMF while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 4,5,6-Trichloropyrimidine serves as a versatile intermediate in pharmaceutical and chemical synthesis. Its 4,5,6-trichloropyrimidine structure allows for participation in various reactions, including nucleophilic substitution at the chlorine atoms and electrophilic substitution at the pyrimidine ring. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The trichloro substituents provide diverse substitution patterns for creating structural analogs. This compound also functions as a building block in the synthesis of fluorescent dyes and bioconjugation reagents. Academic studies employ it as a model compound in Organic Chemistry journals, focusing on the development of novel trichloropyrimidine derivatives based on the 4,5,6-trichloropyrimidine scaffold.
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