5-(trifluoromethyl)-1H-pyrazolo[3,4-c]pyridine
$250.00
CAS No.: 1256793-68-6
Catalog No.: 191958
Purity: 95%
MF: C7H4F3N3
MW: 187.124
Storage: 2-8 degree Celsius
SMILES: FC(C=1C=C2C(=CN1)NN=C2)(F)F
Catalog No.: 191958
Purity: 95%
MF: C7H4F3N3
MW: 187.124
Storage: 2-8 degree Celsius
SMILES: FC(C=1C=C2C(=CN1)NN=C2)(F)F
5-(trifluoromethyl)-1H-pyrazolo[3,4-c]pyridine; CAS No.: 1256793-68-6; 5-(trifluoromethyl)-1H-pyrazolo[3,4-c]pyridine. PROPERTIES: 5-(trifluoromethyl)-1H-pyrazolo[3,4-c]pyridine (CAS No.: 1256793-68-6) presents as a white crystalline powder with a melting point between 185-188 C. The compound features a trifluoromethyl group at position 5 of the pyrazolopyridine heterocycle, imparting significant electron-withdrawing effects and lipophilicity. It exhibits moderate basicity due to the pyridine nitrogen, with a pKa value around 4.2. Solubility characteristics reveal good dissolvability in polar aprotic solvents like acetone and THF, while being sparingly soluble in water due to the hydrophobic trifluoromethyl substituent. The substance is light-sensitive and prone to oxidation upon prolonged exposure to air, necessitating storage in amber glass bottles under nitrogen atmosphere at 2-8 C. Safety precautions include using P320 protective clothing, chemical-resistant gloves, and eye protection due to potential skin sensitization and eye irritation. The compound has a moderate vapor pressure and forms flammable mixtures with air above 55 C. APPLICATIONS: 5-(trifluoromethyl)-1H-pyrazolo[3,4-c]pyridine serves as a versatile intermediate in developing kinase inhibitors for cancer therapy as documented in oncology research. Its trifluoromethyl-substituted heterocycle enables the synthesis of potent JAK/STAT pathway inhibitors with improved pharmacokinetic profiles as reported in pharmaceutical chemistry literature. Additionally, 1256793-68-6 contributes to the development of fluorescent probes for detecting specific protein targets in cellular environments, with several studies highlighting its utility in creating pH-sensitive indicators for monitoring lysosomal conditions during drug delivery. The compound also functions as a building block for agrochemical intermediates used in developing herbicides with novel mechanisms of action, as described in agricultural chemistry literature.
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