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2-(trifluoromethyl)quinolin-5-ol; CAS No.: 41958-06-9; 2-(trifluoromethyl)quinolin-5-ol. PROPERTIES: 2-(trifluoromethyl)quinolin-5-ol is a crystalline material with molecular formula C9H5F3NO. It has a melting point of approximately 100-105 C and exhibits moderate solubility in ethanol and methanol. The compound should be stored in a tightly sealed container at room temperature away from strong oxidizing agents. Safety precautions include avoiding contact with eyes and skin due to its potential to cause serious eye damage and skin irritation. APPLICATIONS: This trifluoromethyl-substituted quinoline derivative is employed in the development of anticancer agents. The hydroxyl group provides a site for PEGylation, enhancing the pharmacokinetic properties of the molecule as reported in cancer research literature. In materials science, 2-(trifluoromethyl)quinolin-5-ol serves as a building block for creating electron-transport materials in organic light-emitting diodes. According to materials chemistry journals, the electron-withdrawing trifluoromethyl group improves charge transport characteristics while the quinoline scaffold provides structural rigidity.