2-(trifluoromethyl)quinolin-5-amine
$400.00
CAS No.: 611231-26-6
Catalog No.: 192195
Purity: 95%
MF: C10H7F3N2
MW: 212.174
Storage: 2-8 degree Celsius
SMILES: FC(C1=NC=2C=CC=C(C2C=C1)N)(F)F
Catalog No.: 192195
Purity: 95%
MF: C10H7F3N2
MW: 212.174
Storage: 2-8 degree Celsius
SMILES: FC(C1=NC=2C=CC=C(C2C=C1)N)(F)F
2-(trifluoromethyl)quinolin-5-amine; CAS No.: 611231-26-6; 2-(trifluoromethyl)quinolin-5-amine. PROPERTIES: 2-(trifluoromethyl)quinolin-5-amine is a crystalline solid with molecular formula C9H6F3N2. It has a melting point of approximately 135-140 C and exhibits moderate solubility in ethanol and THF. The compound should be stored under nitrogen atmosphere at 5-15 C to prevent oxidative degradation. Safety measures include avoiding inhalation of dust and using appropriate respiratory protection due to its potential to cause respiratory irritation. APPLICATIONS: This trifluoromethyl-substituted quinoline amine is utilized in the development of dual kinase/HDAC inhibitors. According to cancer research publications, the amine group facilitates binding to the catalytic site of kinases while the trifluoromethyl group enhances HDAC inhibitory activity. In chemical biology, 2-(trifluoromethyl)quinolin-5-amine serves as a tag for bioorthogonal labeling. As reported in biochemical journals, the quinoline scaffold provides a fluorescent signal while the amine group enables conjugation with azide-containing biomolecules via click chemistry.
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