2-nitro-5-(trifluoromethoxy)benzoic acid
$180.00
CAS No.: 189359-65-7
Catalog No.: 193110
Purity: 95%
MF: C8H4F3NO5
MW: 251.116
Storage: 2-8 degree Celsius
SMILES: [N+](=O)([O-])C1=C(C(=O)O)C=C(C=C1)OC(F)(F)F
Catalog No.: 193110
Purity: 95%
MF: C8H4F3NO5
MW: 251.116
Storage: 2-8 degree Celsius
SMILES: [N+](=O)([O-])C1=C(C(=O)O)C=C(C=C1)OC(F)(F)F
2-nitro-5-(trifluoromethoxy)benzoic acid; CAS No.: 189359-65-7; 2-nitro-5-(trifluoromethoxy)benzoic acid. PROPERTIES: This compound appears as a white crystalline powder with molecular formula C7H4F3N2O4 and a molecular weight of 231.11 g/mol. It demonstrates a melting point in the range of 152-156 C and shows moderate solubility in common organic solvents like methanol and ethyl acetate. The substance is sensitive to hydrolysis and should be stored in dry conditions. Recommended storage involves maintaining in tightly sealed containers at temperatures below 25 C, protected from moisture and light. When handling, standard laboratory safety protocols should be followed, including the use of protective gloves and eye wear, as 2-nitro-5-(trifluoromethoxy)benzoic acid may cause skin irritation. The carboxylic acid group requires careful handling in strongly basic environments. APPLICATIONS: In medicinal chemistry, 2-nitro-5-(trifluoromethoxy)benzoic acid serves as a key intermediate for synthesizing anticancer agents, as documented in pharmaceutical research focusing on kinase inhibitors. Its nitro substituent enables reduction to generate amino groups for further functionalization. Additionally, this compound functions as a building block for preparing agrochemicals with herbicidal activities through coupling reactions. Academic studies have explored its potential in bioconjugation reactions for creating targeted therapeutic agents, as reported in biochemical journals. The benzoic acid framework also facilitates formation of metal-organic frameworks (MOFs), making it valuable for gas storage applications in materials science, as evidenced by studies in crystallography publications.
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