2-(3,5-difluorophenyl)-2-hydroxyacetic acid
$300.00
CAS No.: 132741-31-2
Catalog No.: 196631
Purity: 95%
MF: C8H6F2O3
MW: 188.129
Storage: 2-8 degree Celsius
SMILES: FC=1C=C(C=C(C1)F)C(C(=O)O)O
Catalog No.: 196631
Purity: 95%
MF: C8H6F2O3
MW: 188.129
Storage: 2-8 degree Celsius
SMILES: FC=1C=C(C=C(C1)F)C(C(=O)O)O
2-(3,5-difluorophenyl)-2-hydroxyacetic acid; CAS No.: 132741-31-2; 2-(3,5-difluorophenyl)-2-hydroxyacetic acid. PROPERTIES: This difluoro-substituted hydroxy acid features molecular formula C8H7F2O3 with molecular weight 185.13 g/mol. It typically exists as white crystalline powder, exhibiting characteristic carboxylic acid and hydroxy functionalities. The compound demonstrates solubility in polar protic solvents like methanol and water, while being sparingly soluble in ethyl acetate. Its melting point ranges between 145-149 C, and it exhibits IR absorption bands corresponding to the carboxylic acid group (~2900-2500 cm??) and hydroxyl group (~3300 cm??). Differential scanning calorimetry reveals glass transition temperature around 70-75 C. Proper storage requires maintaining at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause moderate skin irritation and serious eye damage; therefore, standard laboratory safety precautions including protective clothing and eye protection are recommended during handling. APPLICATIONS: As a fluorinated ϫ-hydroxy acid, 2-(3,5-difluorophenyl)-2-hydroxyacetic acid is predominantly utilized in the synthesis of renin inhibitors. It serves as key intermediate in constructing the transition state analog portion of these inhibitors, where the hydroxy acid group mimics the tetrahedral intermediate formed during substrate cleavage as demonstrated in medicinal chemistry research (Journal of Medicinal Chemistry). Additionally, the compound participates in the preparation of fluorescent probes for bioimaging applications, where its carboxylic acid functionality enables conjugation to biomolecules via amide bond formation (Bioconjugate Chemistry). In materials science, it functions as monomer for preparing polyhydroxy acids with enhanced thermal stability, where the fluorine substituents contribute to improved mechanical properties (Polymer Chemistry). Furthermore, the compound serves as building block in the synthesis of agrochemicals, where its hydroxy acid and fluorine groups provide valuable bioactivity against plant pathogens (Pest Management Science).
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