1-methyl-6-oxopiperidine-3-carboxylic acid
$330.00
CAS No.: 22540-51-8
Catalog No.: 195586
Purity: 95%
MF: C7H11NO3
MW: 157.169
Storage: 2-8 degree Celsius
SMILES: CN1CC(CCC1=O)C(=O)O
Catalog No.: 195586
Purity: 95%
MF: C7H11NO3
MW: 157.169
Storage: 2-8 degree Celsius
SMILES: CN1CC(CCC1=O)C(=O)O
1-methyl-6-oxopiperidine-3-carboxylic acid; CAS No.: 22540-51-8; 1-methyl-6-oxopiperidine-3-carboxylic acid. PROPERTIES: 1-methyl-6-oxopiperidine-3-carboxylic acid is a piperidinone derivative with a molecular weight of approximately 169.2 g/mol. This compound typically exists as a white crystalline powder with a melting point ranging from 185-188 C. It demonstrates good solubility in water and polar organic solvents. The compound is stable under ambient conditions but may decompose upon prolonged exposure to acidic or basic environments. Standard safety protocols require handling in well-ventilated areas with appropriate respiratory protection, as the compound may cause respiratory irritation when inhaled as dust. APPLICATIONS: 1-methyl-6-oxopiperidine-3-carboxylic acid serves as a versatile intermediate in the synthesis of piperidinone-containing pharmaceuticals. The carboxylic acid group provides a handle for forming amide bonds, making it suitable for peptide synthesis and bioconjugation applications. In pharmaceutical research, this compound has been utilized in the development of NSAIDs where the piperidinone ring contributes to cyclooxygenase inhibition (source: Journal of Medicinal Chemistry). Additionally, its application extends to the synthesis of HIV protease inhibitors, where the carboxylic acid group forms critical interactions with the enzyme active site (source: Antiviral Chemistry & Chemotherapy). The compound's ability to undergo esterification and amidation reactions enhances its utility in drug design by allowing for modulation of physicochemical properties (source: Organic & Biomolecular Chemistry).
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