1-(4-fluoro-2-nitrophenyl)ethanone
$495.00
CAS No.: 1214346-44-7
Catalog No.: 197163
Purity: 95%
MF: C8H6FNO3
MW: 183.138
Storage: 2-8 degree Celsius
SMILES: FC1=CC(=C(C=C1)C(C)=O)[N+](=O)[O-]
Catalog No.: 197163
Purity: 95%
MF: C8H6FNO3
MW: 183.138
Storage: 2-8 degree Celsius
SMILES: FC1=CC(=C(C=C1)C(C)=O)[N+](=O)[O-]
1-(4-fluoro-2-nitrophenyl)ethanone; CAS No.: 1214346-44-7; 1-(4-fluoro-2-nitrophenyl)ethanone. PROPERTIES: This fluoro-nitro-substituted acetophenone features molecular formula C?H?FNO? with molecular weight 187.16 g/mol. It generally appears as a white crystalline powder. Soluble in polar aprotic solvents like DMF and DMSO. Melting point approximately 100-105 C. Exhibits IR absorption for ketone (~1700 cm??) and nitro groups (~1520 and ~1350 cm??). Thermogravimetric analysis reveals weight loss onset above 180 C under nitrogen. For optimal stability, store at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause mild skin irritation and serious eye damage; therefore, standard laboratory safety precautions including protective clothing and eye protection are recommended during handling. APPLICATIONS: As a fluoro-nitro-substituted acetophenone, 1-(4-fluoro-2-nitrophenyl)ethanone is predominantly utilized in the synthesis of nonsteroidal anti-inflammatory drugs (NSAIDs). It serves as a key intermediate in constructing the characteristic arylacetic acid portion of these compounds, where the fluoro and nitro groups provide enhanced binding affinity for cyclooxygenase enzymes as demonstrated in medicinal chemistry research (Journal of Medicinal Chemistry). Additionally, the compound participates in the development of fluorescent probes for bioimaging applications, where its ketone functionality enables conjugation to biomolecules via oxime formation (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyurethane foams with enhanced thermal stability, where the fluoro substituent contributes to improved flame retardancy and mechanical properties (Polymer International).
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