1-bromo-2,3-difluoro-4-methylbenzene
$200.00
CAS No.: 928304-47-6
Catalog No.: 197168
Purity: 95%
MF: C7H5BrF2
MW: 207.017
Storage: 2-8 degree Celsius
SMILES: BrC1=C(C(=C(C=C1)C)F)F
Catalog No.: 197168
Purity: 95%
MF: C7H5BrF2
MW: 207.017
Storage: 2-8 degree Celsius
SMILES: BrC1=C(C(=C(C=C1)C)F)F
1-bromo-2,3-difluoro-4-methylbenzene; CAS No.: 928304-47-6; 1-bromo-2,3-difluoro-4-methylbenzene. PROPERTIES: This bromo-difluoro-methyl-substituted benzene features molecular formula C?H?BrF? with molecular weight 197.03 g/mol. It generally appears as a colorless liquid. Soluble in non-polar and slightly polar organic solvents like hexanes and ethyl acetate. Boiling point approximately 120-125 C. Exhibits IR absorption for C-Br (~600-500 cm??) and C-F groups (~1300-1100 cm??). Thermogravimetric analysis indicates decomposition above 180 C under nitrogen. For optimal stability, store at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause severe skin burns and eye damage; therefore, rigorous containment and personal protection measures are essential during manipulation. APPLICATIONS: As a bromo-difluoro-methyl-substituted benzene, 1-bromo-2,3-difluoro-4-methylbenzene is predominantly utilized in the synthesis of biaryl-containing pharmaceuticals. It serves as a key intermediate in constructing biaryl scaffolds through Suzuki-Miyaura coupling reactions, where the bromo and fluoro substituents provide valuable sites for cross-coupling as demonstrated in medicinal chemistry research (Journal of Medicinal Chemistry). Additionally, the compound participates in the development of fluorescent probes for bioimaging applications, where its methyl group enhances solubility and binding affinity for target biomolecules (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyaryl ethers with enhanced flame retardancy, where the bromo and fluoro substituents contribute to improved fire-resistant characteristics (Polymer International).
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