1-(2-fluoro-4-hydroxyphenyl)ethanone
$300.00
CAS No.: 98619-07-9
Catalog No.: 196638
Purity: 95%
MF: C8H7FO2
MW: 154.14
Storage: 2-8 degree Celsius
SMILES: FC1=C(C=CC(=C1)O)C(C)=O
Catalog No.: 196638
Purity: 95%
MF: C8H7FO2
MW: 154.14
Storage: 2-8 degree Celsius
SMILES: FC1=C(C=CC(=C1)O)C(C)=O
1-(2-fluoro-4-hydroxyphenyl)ethanone; CAS No.: 98619-07-9; 1-(2-fluoro-4-hydroxyphenyl)ethanone. PROPERTIES: This fluoro-substituted acetophenone derivative features molecular formula C8H7FO2 with molecular weight 150.14 g/mol. It generally appears as white crystalline powder, exhibiting characteristic ketone reactivity. The compound demonstrates solubility in polar aprotic solvents like ethyl acetate and dichloromethane, while being sparingly soluble in hexanes. Its melting point ranges between 108-112 C, and it exhibits IR absorption bands corresponding to the ketone group (~1710 cm??) and hydroxyl group (~3300 cm??). Thermogravimetric analysis reveals decomposition onset above 180 C under nitrogen atmosphere. For optimal stability, 1-(2-fluoro-4-hydroxyphenyl)ethanone should be stored at 2-8 C in tightly sealed amber glass containers, protected from moisture and prolonged light exposure. As with ketone compounds, it may cause moderate skin irritation and serious eye damage; therefore, standard laboratory safety precautions including nitrile gloves, safety goggles, and proper ventilation are recommended during handling. APPLICATIONS: As a hydroxyacetophenone derivative, 1-(2-fluoro-4-hydroxyphenyl)ethanone is predominantly utilized in the synthesis of nonsteroidal anti-inflammatory drugs (NSAIDs). It serves as key intermediate in constructing coxib-class COX-2 inhibitors, where the hydroxyl group undergoes sulfonation to form the characteristic sulfonamide pharmacophore as demonstrated in medicinal chemistry research (Journal of Medicinal Chemistry). Additionally, the compound participates in the preparation of fluorescent probes for bioimaging applications, where its ketone functionality enables conjugation to biomolecules via oxime formation (Bioconjugate Chemistry). In materials science, it functions as monomer for preparing polyhydroxy ketone polymers with enhanced thermal stability, where the fluorine substituent contributes to improved flame retardancy (Polymer Chemistry). Furthermore, the compound serves as building block in the synthesis of agrochemicals, where its hydroxyl and fluorine groups provide valuable bioactivity against plant pathogens (Pest Management Science).
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