tert-Butyl N-[2-(4-bromophenyl)-2-oxoethyl]carbamate
$300.00
CAS No.: 339185-70-5
Catalog No.: 193139
Purity: 95%
MF: C13H16BrNO3
MW: 314.179
Storage: 2-8 degree Celsius
SMILES: BrC1=CC=C(C=C1)C(CNC(OC(C)(C)C)=O)=O
Catalog No.: 193139
Purity: 95%
MF: C13H16BrNO3
MW: 314.179
Storage: 2-8 degree Celsius
SMILES: BrC1=CC=C(C=C1)C(CNC(OC(C)(C)C)=O)=O
tert-Butyl N-[2-(4-bromophenyl)-2-oxoethyl]carbamate; CAS No.: 339185-70-5 tert-Butyl N-[2-(4-bromophenyl)-2-oxoethyl]carbamate. PROPERTIES: tert-Butyl N-[2-(4-bromophenyl)-2-oxoethyl]carbamate is a crystalline solid with a molecular weight of 331.2 g/mol. It has a melting point between 100-105 C and exhibits moderate solubility in ethyl acetate and methylene chloride. The compound exhibits typical carbamate reactivity and should be handled with care to prevent hydrolysis. When working with this compound, protective equipment including gloves and eye protection should be worn. Storage should be in a tightly sealed container at temperatures below 10 C, preferably under an inert atmosphere to prevent degradation. The compound is sensitive to acidic and basic conditions, which may cause hydrolysis of the carbamate group. APPLICATIONS: tert-Butyl N-[2-(4-bromophenyl)-2-oxoethyl]carbamate serves as a protected amine intermediate in the synthesis of pharmaceuticals and advanced materials. Its bromine substituent provides a useful handle for cross-coupling reactions, enabling the preparation of various substituted aromatic systems. Derivatives of this compound have been explored in the development of kinase inhibitors and other targeted therapeutics, as reported in the Journal of Medicinal Chemistry. The carbamate protection allows for controlled deprotection and further functionalization in synthetic sequences. Additionally, the compound can be utilized in the synthesis of molecular sensors and fluorescent probes, as described in Chemical Communications. The combination of the Boc protection and the brominated aromatic group makes this compound particularly useful in solid-phase peptide synthesis and the preparation of combinatorial libraries for drug discovery, as highlighted in the Journal of Combinatorial Chemistry.
Reviews
Write Your Own Review