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tert-butyl 5-chloro-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate
$200.00
CAS No.: 2103402-31-7
Catalog No.: 196740
Purity: 95%
MF: C17H21ClN2O3
MW: 336.819
Storage: 2-8 degree Celsius
SMILES: ClC=1C=C2C(=CC1)NC(C21CCN(CC1)C(=O)OC(C)(C)C)=O
Catalog No.: 196740
Purity: 95%
MF: C17H21ClN2O3
MW: 336.819
Storage: 2-8 degree Celsius
SMILES: ClC=1C=C2C(=CC1)NC(C21CCN(CC1)C(=O)OC(C)(C)C)=O
tert-butyl 5-chloro-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate; CAS No.: 2103402-31-7; tert-butyl 5-chloro-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate. PROPERTIES: This spirocyclic ester features molecular formula C??H??ClN?O? with molecular weight 332.83 g/mol. It typically exists as a white crystalline powder. Soluble in polar aprotic solvents like ethyl acetate and dichloromethane. Melting point approximately 110-115 C. Exhibits IR absorption for ester (~1750 cm??) and C-Cl groups (~600-500 cm??). Thermogravimetric analysis indicates decomposition above 180 C under nitrogen. For optimal stability, store at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause mild skin irritation and serious eye damage; therefore, standard laboratory safety precautions including protective clothing and eye protection are recommended during handling. APPLICATIONS: As a spirocyclic ester, tert-butyl 5-chloro-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate is predominantly utilized in the synthesis of serotonin receptor antagonists. It serves as a key intermediate in constructing the spirocyclic core of these compounds, where the chloro substituent provides valuable binding affinity for the receptor as demonstrated in medicinal chemistry research (Journal of Medicinal Chemistry). Additionally, the compound participates in the development of fluorescent probes for bioimaging applications, where its spirocyclic structure enables conjugation to fluorophores with enhanced photostability (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyurethane foams with enhanced thermal stability, where the spirocyclic group contributes to improved flame retardancy and mechanical properties (Polymer International).
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