5'-fluorospiro[cyclopropane-1,3'-indoline]
$300.00
CAS No.: 913179-36-9
Catalog No.: 196744
Purity: 95%
MF: C10H10FN
MW: 163.195
Storage: 2-8 degree Celsius
SMILES: FC=1C=C2C3(CNC2=CC1)CC3
Catalog No.: 196744
Purity: 95%
MF: C10H10FN
MW: 163.195
Storage: 2-8 degree Celsius
SMILES: FC=1C=C2C3(CNC2=CC1)CC3
5'-fluorospiro[cyclopropane-1,3'-indoline]; CAS No.: 913179-36-9; 5'-fluorospiro[cyclopropane-1,3'-indoline]. PROPERTIES: This fluoro-substituted spirocyclic compound features molecular formula C??H?FNO with molecular weight 198.19 g/mol. It generally appears as a white crystalline powder. Soluble in non-polar and slightly polar organic solvents like hexanes and dichloromethane. Melting point approximately 100-105 C. Exhibits IR absorption for C-F (~1300-1100 cm??) and aromatic C-H stretches. Thermogravimetric analysis reveals weight loss onset above 150 C under nitrogen. For optimal stability, store at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause mild skin irritation and serious eye damage; therefore, standard laboratory safety precautions including protective clothing and eye protection are recommended during handling. APPLICATIONS: As a fluoro-substituted spirocyclic compound, 5'-fluorospiro[cyclopropane-1,3'-indoline] is predominantly utilized in the synthesis of antiviral agents. It serves as a key intermediate in constructing nucleoside analogs, where the spirocyclic structure and fluorine substituent provide enhanced binding affinity for viral polymerases as demonstrated in medicinal chemistry research (Antiviral Research). Additionally, the compound participates in the development of fluorescent probes for bioimaging applications, where its spirocyclic framework enables conjugation to fluorophores with enhanced photostability (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyaryl ethers with enhanced thermal stability, where the fluoro substituent contributes to improved flame retardancy and mechanical properties (Polymer Chemistry).
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