tert-butyl 5,5-difluoro-2-(hydroxymethyl)piperidine-1-carboxylate
$450.00
CAS No.: 1255666-39-7
Catalog No.: 171962
Purity: 95%
MF: C11H19F2NO3
MW: 251.273
Storage: 2-8 degree Celsius
SMILES: CC(C)(C)OC(=O)N1CC(F)(F)CCC1CO
Catalog No.: 171962
Purity: 95%
MF: C11H19F2NO3
MW: 251.273
Storage: 2-8 degree Celsius
SMILES: CC(C)(C)OC(=O)N1CC(F)(F)CCC1CO
tert-butyl 5,5-difluoro-2-(hydroxymethyl)piperidine-1-carboxylate; CAS No.: 1255666-39-7; ChemShuttle's expertise in CRO chemical synthesis is showcased through tert-butyl 5,5-difluoro-2-(hydroxymethyl)piperidine-1-carboxylate. This difluorinated piperidine alcohol serves as a key intermediate for ADC linker development. The hydroxymethyl group enables conjugation to cytotoxic payloads via carbamate or carbonate linkages. The gem-difluoro substitution enhances metabolic stability compared to non-fluorinated analogs. The company provides scale-up services under controlled atmosphere conditions to prevent oxidation of the alcohol moiety. Applications include site-specific antibody conjugation technologies, with technical support for optimizing linker hydrophilicity to improve ADC pharmacokinetics.
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