tert-butyl (3S)-3-fluoro-4-oxopiperidine-1-carboxylate
$480.00
CAS No.: 1450879-67-0
Catalog No.: 195590
Purity: 95%
MF: C10H16FNO3
MW: 217.24
Storage: 2-8 degree Celsius
SMILES: F[C@H]1CN(CCC1=O)C(=O)OC(C)(C)C
Catalog No.: 195590
Purity: 95%
MF: C10H16FNO3
MW: 217.24
Storage: 2-8 degree Celsius
SMILES: F[C@H]1CN(CCC1=O)C(=O)OC(C)(C)C
tert-butyl (3S)-3-fluoro-4-oxopiperidine-1-carboxylate; CAS No.: 1450879-67-0; tert-butyl (3S)-3-fluoro-4-oxopiperidine-1-carboxylate. PROPERTIES: tert-butyl (3S)-3-fluoro-4-oxopiperidine-1-carboxylate is a fluorinated piperidine derivative with a molecular weight of approximately 227.2 g/mol. This compound typically exists as a white crystalline powder with a melting point between 110-115 C. It demonstrates moderate solubility in polar organic solvents and limited aqueous solubility. The compound is stable under ambient conditions but may decompose upon exposure to strong acidic conditions. For optimal storage, it should be kept in a tightly sealed container at room temperature. Standard safety precautions include the use of chemical-resistant gloves and eye protection due to potential irritant properties. APPLICATIONS: tert-butyl (3S)-3-fluoro-4-oxopiperidine-1-carboxylate serves as a key intermediate in the synthesis of fluorinated piperidine-containing pharmaceuticals. The fluoro substitution at position 3 provides steric and electronic effects that enhance binding interactions with biological targets. In pharmaceutical research, this compound has been utilized in the development of HIV integrase inhibitors where the fluorine atom contributes to enzyme binding affinity (source: Journal of Medicinal Chemistry). Additionally, its application extends to the synthesis of kinase inhibitors, where the oxopiperidine group forms hydrogen bonds with enzyme active sites (source: Bioorganic & Medicinal Chemistry). The compound's ability to undergo selective fluorination reactions further enhances its utility in drug design by allowing for precise modulation of pharmacokinetic properties (source: Organic Process Research & Development).
Reviews
Write Your Own Review