3,3-difluorocyclobutane-1-carbaldehyde
$900.00
CAS No.: 1246765-49-0
Catalog No.: 195568
Purity: 95%
MF: C5H6F2O
MW: 120.098
Storage: 2-8 degree Celsius
SMILES: FC1(CC(C1)C=O)F
Catalog No.: 195568
Purity: 95%
MF: C5H6F2O
MW: 120.098
Storage: 2-8 degree Celsius
SMILES: FC1(CC(C1)C=O)F
3,3-difluorocyclobutane-1-carbaldehyde; CAS No.: 1246765-49-0; 3,3-difluorocyclobutane-1-carbaldehyde. PROPERTIES: 3,3-difluorocyclobutane-1-carbaldehyde is a colorless liquid with molecular formula C5H6F2O. It exhibits a boiling point around 75-80 C at 760 mmHg and moderate thermal stability. The compound shows good solubility in non-polar organic solvents like hexane and moderate solubility in ethyl acetate. Recommended storage conditions include maintaining temperatures below 25 C in sealed containers. Safety considerations involve using explosion-proof equipment when handling due to potential flammability and employing proper engineering controls to minimize exposure to aldehyde vapors. APPLICATIONS: This difluorinated cyclobutane aldehyde serves as a valuable intermediate in the synthesis of HIV integrase inhibitors, where the 3,3-difluorocyclobutane-1-carbaldehyde group contributes to binding within the integrase active site (Journal of Medicinal Chemistry). In fluorochemistry, the compound is used as a building block for developing novel refrigerants with low global warming potential due to its cyclobutane structure (Journal of Fluorine Chemistry). Furthermore, its aldehyde functionality enables reductive amination reactions for the preparation of diverse secondary amines used in medicinal chemistry library development (ACS Combinatorial Science).
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