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tert-butyl 3,3-difluoro-4-methylpiperidine-1-carboxylate; CAS No.: 1373502-94-3; ChemShuttle's expertise in CRO chemical synthesis is showcased through tert-butyl 3,3-difluoro-4-methylpiperidine-1-carboxylate. This difluorinated piperidine serves as a building block for fluorinated macrocycle synthesis. The methyl group enhances lipophilicity for membrane permeability optimization, while the difluoro substitution restricts ring puckering. Applications include ion channel modulator development and fluorinated crown ether synthesis. The company provides X-ray crystallography data confirming chair conformation preferences. Technical support includes optimization of ring-closing metathesis conditions.