tert-butyl 2-chloro-5-nitrobenzoate
$250.00
CAS No.: 55233-05-1
Catalog No.: 193144
Purity: 95%
MF: C11H12ClNO4
MW: 257.673
Storage: 2-8 degree Celsius
SMILES: ClC1=C(C(=O)OC(C)(C)C)C=C(C=C1)[N+](=O)[O-]
Catalog No.: 193144
Purity: 95%
MF: C11H12ClNO4
MW: 257.673
Storage: 2-8 degree Celsius
SMILES: ClC1=C(C(=O)OC(C)(C)C)C=C(C=C1)[N+](=O)[O-]
tert-butyl 2-chloro-5-nitrobenzoate; CAS No.: 55233-05-1 tert-butyl 2-chloro-5-nitrobenzoate. PROPERTIES: tert-butyl 2-chloro-5-nitrobenzoate is a crystalline solid with a molecular weight of 247.7 g/mol. It has a melting point between 75-80 C and exhibits low water solubility. The compound is moderately soluble in organic solvents such as methylene chloride and acetone. When handling tert-butyl 2-chloro-5-nitrobenzoate, care should be taken to avoid skin contact and inhalation of dust. Protective equipment including chemical-resistant gloves and a lab coat is recommended. The compound should be stored in a tightly sealed container at temperatures below 20 C in a cool, dark place. It is sensitive to light, which may cause gradual decomposition of the nitro group. APPLICATIONS: tert-butyl 2-chloro-5-nitrobenzoate serves as a valuable intermediate in the synthesis of pharmaceuticals and specialty chemicals. Its nitro group provides a useful handle for reduction to amine functionality, enabling diverse chemical transformations. Derivatives of this compound have been explored in the development of antimicrobial agents, as reported in the Journal of Medicinal Chemistry. The tert-butyl ester group allows for controlled hydrolysis to the corresponding carboxylic acid. Additionally, tert-butyl 2-chloro-5-nitrobenzoate can be utilized in the synthesis of liquid crystalline materials for display technologies, as described in Liquid Crystals. The chlorinated aromatic group also makes it suitable for use in organic electronics as a building block for semiconducting polymers, as noted in Advanced Materials. The combination of the tert-butyl ester and nitro groups provides multiple points of chemical modification, making this compound a versatile building block in medicinal chemistry.
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