tert-butyl 2-(3-aminophenyl)piperidine-1-carboxylate
$350.00
CAS No.: 908334-27-0
Catalog No.: 195604
Purity: 95%
MF: C16H24N2O2
MW: 276.38
Storage: 2-8 degree Celsius
SMILES: NC=1C=C(C=CC1)C1N(CCCC1)C(=O)OC(C)(C)C
Catalog No.: 195604
Purity: 95%
MF: C16H24N2O2
MW: 276.38
Storage: 2-8 degree Celsius
SMILES: NC=1C=C(C=CC1)C1N(CCCC1)C(=O)OC(C)(C)C
tert-butyl 2-(3-aminophenyl)piperidine-1-carboxylate; CAS No.: 908334-27-0; tert-butyl 2-(3-aminophenyl)piperidine-1-carboxylate. PROPERTIES: tert-butyl 2-(3-aminophenyl)piperidine-1-carboxylate is a piperidine derivative with a molecular weight of approximately 273.3 g/mol. This compound typically exists as a white crystalline powder with a melting point between 105-110 C. It demonstrates moderate solubility in common organic solvents and limited aqueous solubility. The compound is stable under ambient conditions but may undergo hydrolysis under strongly acidic conditions. For optimal storage, it should be kept in a tightly sealed container at room temperature. Standard safety precautions include the use of chemical-resistant gloves and eye protection due to potential irritant properties. APPLICATIONS: tert-butyl 2-(3-aminophenyl)piperidine-1-carboxylate serves as a key intermediate in the synthesis of phenylpiperidine-containing pharmaceuticals. The aminophenyl group provides a platform for forming hydrogen bonds with biological targets, enhancing drug-receptor interactions. In medicinal chemistry, this compound has been employed in the development of antipsychotic agents where the phenylpiperidine scaffold contributes to dopamine receptor antagonism (source: Journal of Medicinal Chemistry). Additionally, its application extends to the synthesis of antidepressant compounds, where the amino group participates in serotonergic activity modulation (source: European Journal of Medicinal Chemistry). The compound's ability to undergo selective protection and deprotection strategies enhances its utility in complex molecule synthesis (source: Organic Process Research & Development).
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