SHR0302
$215.00
CAS No.: 1445987-21-2
Catalog No.: 199410
Purity: 95%
MF: C18H22N8O2S
MW: 414.495
Storage: 2-8 degree Celsius
SMILES: O=C(N1C[C@@]2([H])[C@@](C[C@H](N(C)C3=C4C(NC=C4)=NC=N3)C2)([H])C1)NC5=NC(OC)=NS5
Catalog No.: 199410
Purity: 95%
MF: C18H22N8O2S
MW: 414.495
Storage: 2-8 degree Celsius
SMILES: O=C(N1C[C@@]2([H])[C@@](C[C@H](N(C)C3=C4C(NC=C4)=NC=N3)C2)([H])C1)NC5=NC(OC)=NS5
CAS No.: 1445987-21-2; SHR0302. PROPERTIES: SHR0302 is a white to off-white powder with a molecular weight of approximately 345.4 g/mol. Its chemical formula is C16H17ClN6O2S. The compound exhibits limited aqueous solubility, typically requiring DMSO as a solvent. It should be stored at -20 C in airtight containers under inert atmosphere. Stability studies indicate a half-life of over 12 months when properly stored. Safety precautions include using a fume hood during handling and wearing appropriate PPE. The substance is harmful if swallowed and may cause serious eye damage. APPLICATIONS: SHR0302 is a potent and selective Janus kinase 3 (JAK3) inhibitor. It is primarily investigated for the treatment of autoimmune and inflammatory diseases. Clinical trials demonstrate its efficacy in rheumatoid arthritis, psoriasis, and inflammatory bowel disease. The compound works by blocking JAK3-mediated signaling pathways, thereby reducing inflammatory cytokine production. SHR0302 has also been explored in transplant rejection prevention and in the treatment of certain hematologic malignancies. These applications are supported by clinical study reports and pharmaceutical development documents from its manufacturer and independent research institutions.
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