(S)-1-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid

(S)-1-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid; CAS No.: 1187933-14-7; (S)-1-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid. PROPERTIES: (S)-1-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid appears as a white powder with molecular weight 303.35 g/mol. It has a melting point between 180-185 C and shows limited aqueous solubility but good solubility in DMSO. Proper storage involves maintaining in a sealed container at room temperature away from acidic vapors. Safety precautions include using protective gloves and eye protection as this compound may cause skin and eye irritation. APPLICATIONS: This Boc-protected tetrahydroquinoline carboxylic acid is employed in peptide synthesis. The carboxylic acid group forms amide bonds with amino acids as reported in biochemical research journals. In medicinal chemistry, (S)-1-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid serves as a building block for creating -turn mimetics. According to pharmaceutical patents, the tetrahydroquinoline framework enhances peptide stability while the Boc group provides temporary protection during synthesis.