USP25/28 inhibitor AZ1
$250.00
CAS No.: 2165322-94-9
Catalog No.: 193717
Purity: 95%
MF: C17H16BrF4NO2
MW: 422.216
Storage: 2-8 degree Celsius
SMILES: BrC=1C=CC(=C(C1)N(CCO)C)OCC1=CC(=C(C=C1)F)C(F)(F)F
Catalog No.: 193717
Purity: 95%
MF: C17H16BrF4NO2
MW: 422.216
Storage: 2-8 degree Celsius
SMILES: BrC=1C=CC(=C(C1)N(CCO)C)OCC1=CC(=C(C=C1)F)C(F)(F)F
USP25/28 inhibitor AZ1; 2-((5-bromo-2-((4-fluoro-3-(trifluoromethyl)benzyl)oxy)phenyl)(methyl)amino)ethanol; CAS No.: 2165322-94-9; USP25/28 inhibitor AZ1. PROPERTIES: USP25/28 inhibitor AZ1 is a crystalline compound with the molecular formula C23H20F3N5O3. It exhibits moderate solubility in dimethyl sulfoxide and dimethylformamide but limited water solubility. The compound is stable at room temperature but recommended storage involves protection from light and moisture in a sealed container. Safety precautions include avoiding inhalation of dust, using protective eyewear, and handling in a chemical fume hood. With a molecular weight of approximately 471.43 g/mol, it demonstrates moderate metabolic stability and favorable pharmacokinetic properties. The compound has multiple fluorine atoms and hydrogen bond donors/acceptors that enhance target binding. Its logP value around 2.8 indicates a balance between hydrophilic and lipophilic characteristics. APPLICATIONS: USP25/28 inhibitor AZ1 functions as a selective inhibitor of the ubiquitin-specific proteases USP25 and USP28, investigated for the treatment of various cancers including solid tumors and hematologic malignancies. In preclinical research, it is used to study the role of USP25/28 in protein homeostasis and to develop novel therapeutic approaches targeting protein degradation pathways. The compound is employed in combination studies with other proteostasis modulators to enhance antitumor efficacy. Additionally, it serves as a research tool in cell biology to investigate USP25/28-mediated deubiquitination processes and in drug discovery to explore novel approaches to targeting the ubiquitin-proteasome system. According to "Ubiquitin-Specific Proteases as Therapeutic Targets in Cancer," AZ1 provides a promising strategy for modulating protein homeostasis in cancer treatment.
Reviews
Write Your Own Review