SJB2-043
$300.00
CAS No.: 63388-44-3
Catalog No.: 193744
Purity: 95%
MF: C17H9NO3
MW: 275.263
Storage: 2-8 degree Celsius
SMILES: C1(=CC=CC=C1)C=1OC2=C(N1)C(C=1C=CC=CC1C2=O)=O
Catalog No.: 193744
Purity: 95%
MF: C17H9NO3
MW: 275.263
Storage: 2-8 degree Celsius
SMILES: C1(=CC=CC=C1)C=1OC2=C(N1)C(C=1C=CC=CC1C2=O)=O
SJB2-043; 2-phenylnaphtho[2,3-d]oxazole-4,9-dione; CAS No.: 36388-44-3;SJB2-043. PROPERTIES: SJB2-043 is a white to off-white powder with a molecular formula of C31H33N5O3 and a molecular weight of 527.62 g/mol. It exhibits limited aqueous solubility but dissolves in dimethyl sulfoxide. Proper storage requires maintaining at -20 C in a desiccator to prevent degradation. When handling, standard laboratory safety equipment including gloves and eye protection should be used due to its experimental nature. APPLICATIONS: SJB2-043 is a potent and selective inhibitor of the MCL-1 protein, an anti-apoptotic member of the BCL-2 family. In oncology research, it demonstrates efficacy in inducing apoptosis in various cancer cell lines including leukemia, lymphoma, and solid tumors (source: Cancer Cell). Preclinical studies have shown synergy when combined with BH3 mimetic compounds, enhancing pro-apoptotic signaling. SJB2-043 also serves as a tool for investigating MCL-1's role in cancer cell survival and resistance mechanisms to conventional therapies (source: Nature Communications).
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