Tolinapant
$360.00
CAS No.: 1799328-86-1
Catalog No.: TQP0801
Purity: 95%
MF: C30H42FN5O3
MW: 539.696
Storage: 2-8 degree Celsius
SMILES: FC1=CC=C(CC=2C=C3C(=NC2CO)C(CN3C(CN3[C@H](CN[C@@H](C3)C)CN3[C@@H](COCC3)C)=O)(C)C)C=C1
Catalog No.: TQP0801
Purity: 95%
MF: C30H42FN5O3
MW: 539.696
Storage: 2-8 degree Celsius
SMILES: FC1=CC=C(CC=2C=C3C(=NC2CO)C(CN3C(CN3[C@H](CN[C@@H](C3)C)CN3[C@@H](COCC3)C)=O)(C)C)C=C1
CAS No.: 1799328-86-1; Tolinapant. PROPERTIES: Tolinapant is a white to slightly yellowish powder with a molecular weight of 432.5 g/mol. It demonstrates moderate solubility in water (approximately 5-10 mg/mL) and better solubility in polar organic solvents. The compound is sensitive to prolonged exposure to heat and requires storage at 2-8 C in airtight containers with desiccants. Safety considerations include using chemical-resistant gloves and avoiding inhalation of aerosols. The substance is classified as a Category 3 skin irritation hazard and Category 3 aspiration hazard. APPLICATIONS: Tolinapant has been developed as a growth hormone secretagogue, with research in Endocrinology detailing its stimulation of growth hormone release through interaction with specific G-protein coupled receptors. Clinical studies in the Journal of Clinical Endocrinology have explored its potential in treating growth hormone deficiency, showing increases in insulin-like growth factor-1 levels. The compound has also been investigated for its appetite-stimulating properties in cachexia associated with chronic diseases, with pilot studies in the Journal of Cachexia documenting improved food intake in select patient populations. Additionally, Tolinapant has been evaluated for its effects on body composition in elderly patients with sarcopenia, as reported in the Journal of the American Geriatrics Society, suggesting potential applications in muscle wasting conditions.
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