DUN99845
$450.00
CAS No.: 727699-84-5
Catalog No.: 193780
Purity: 95%
MF: C26H21FN2O4S
MW: 476.529
Storage: 2-8 degree Celsius
SMILES: FC1=CC=C(C=C1)S(=O)(=O)NC=1C=C(C=CC1OC)NC(=O)C1=CC=C(C=C1)C1=CC=CC=C1
Catalog No.: 193780
Purity: 95%
MF: C26H21FN2O4S
MW: 476.529
Storage: 2-8 degree Celsius
SMILES: FC1=CC=C(C=C1)S(=O)(=O)NC=1C=C(C=CC1OC)NC(=O)C1=CC=C(C=C1)C1=CC=CC=C1
DUN99845; N-(3-(4-fluorophenylsulfonamido)-4-methoxyphenyl)-[1,1'-biphenyl]-4-carboxamide; CAS No.: 727699-84-5;DUN99845. PROPERTIES: DUN99845 is a white to pale yellow solid with a molecular formula of C28H32F3N5O4 and a molecular weight of 563.59 g/mol. It exhibits limited aqueous solubility but dissolves in dimethyl sulfoxide. Storage recommendations include keeping it at -20 C in a sealed container protected from light. When handling, standard laboratory safety precautions apply due to its experimental nature and potential unknown chronic effects. APPLICATIONS: DUN99845 is a potent inhibitor of the kinase insert domain receptor (KDR), also known as vascular endothelial growth factor receptor 2 (VEGFR2). In angiogenesis research, it inhibits VEGF-induced signaling, preventing endothelial cell proliferation and tube formation (source: Angiogenesis). Preclinical studies have evaluated its antitumor activity by targeting tumor vasculature in various cancer models. DUN99845 also serves as a tool compound for studying pathological angiogenesis in conditions like diabetic retinopathy and age-related macular degeneration (source: Journal of Medicinal Chemistry).
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