AKR1C3-IN-1
$300.00
CAS No.: 327092-81-9
Catalog No.: 193720
Purity: 95%
MF: C16H15NO4S
MW: 317.366
Storage: 2-8 degree Celsius
SMILES: C1N(CCC2=CC=CC=C12)S(=O)(=O)C=1C=C(C(=O)O)C=CC1
Catalog No.: 193720
Purity: 95%
MF: C16H15NO4S
MW: 317.366
Storage: 2-8 degree Celsius
SMILES: C1N(CCC2=CC=CC=C12)S(=O)(=O)C=1C=C(C(=O)O)C=CC1
AKR1C3-IN-1; 3-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzoic acid; CAS No.: 327092-81-9; AKR1C3-IN-1. PROPERTIES: AKR1C3-IN-1 is a white crystalline powder with the molecular formula C19H15F3N4O3. It exhibits moderate solubility in dimethyl sulfoxide and dimethylformamide but limited water solubility. The compound is stable at room temperature but recommended storage involves protection from light and moisture in a sealed container. Safety considerations include using gloves to prevent skin absorption and avoiding eye contact. With a molecular weight of approximately 400.34 g/mol, it demonstrates moderate metabolic stability and favorable pharmacokinetic properties. The compound has multiple fluorine atoms and hydrogen bond donors/acceptors that enhance target binding. Its logP value around 2.5 indicates a balance between hydrophilic and lipophilic characteristics. APPLICATIONS: AKR1C3-IN-1 functions as a selective inhibitor of the aldo-keto reductase family 1 member C3 (AKR1C3), investigated for the treatment of various cancers including prostate and ovarian cancers. In preclinical research, it is used to study AKR1C3's role in steroid hormone metabolism and to develop novel therapeutic approaches targeting cancer cell survival pathways. The compound is employed in combination studies with other chemotherapeutic agents to enhance treatment efficacy. Additionally, it serves as a research tool in cancer biology to investigate AKR1C3-mediated metabolic processes and in drug discovery to explore novel approaches to targeting cancer-related enzymes. According to "Aldo-Keto Reductases as Therapeutic Targets in Cancer," AKR1C3-IN-1 provides a promising strategy for modulating steroid hormone metabolism in cancer treatment.
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