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AG 1406; 2-(4-hydroxy-3,5-diisopropylbenzylidene)malononitrile; CAS No.: 71308-34-4; AG 1406. PROPERTIES: AG 1406 is a small molecule compound appearing as a white to off-white solid. This compound has a molecular weight in the range of 300-400 g/mol. It demonstrates limited water solubility but is soluble in organic solvents like DMSO. AG 1406 should be stored at -20 C in a tightly sealed container. It is sensitive to moisture and light. Safety considerations include potential skin and eye irritation, so protective measures are advised. APPLICATIONS: AG 1406 is used in signal transduction research as an inhibitor of specific tyrosine kinases. It facilitates the study of receptor tyrosine kinase pathways and their role in cell proliferation and differentiation. In pharmacology, AG 1406 serves as a tool to investigate the therapeutic potential of tyrosine kinase inhibition in various disease models. These applications are reported in biochemistry literature and pharmacology research papers.