2'-Deoxy-5'-O-DMT-2'-fluorouridine
$300.00
CAS No.: 146954-74-7
Catalog No.: 195182
Purity: 95%
MF: C30H29FN2O7
MW: 548.567
Storage: 2-8 degree Celsius
SMILES: COC1=CC=C(C=C1)C(OC[C@@H]1[C@H]([C@H]([C@@H](O1)N1C(NC(C=C1)=O)=O)F)O)(C1=CC=CC=C1)C1=CC=C(C=C1)OC
Catalog No.: 195182
Purity: 95%
MF: C30H29FN2O7
MW: 548.567
Storage: 2-8 degree Celsius
SMILES: COC1=CC=C(C=C1)C(OC[C@@H]1[C@H]([C@H]([C@@H](O1)N1C(NC(C=C1)=O)=O)F)O)(C1=CC=CC=C1)C1=CC=C(C=C1)OC
2'-Deoxy-5'-O-DMT-2'-fluorouridine; 1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; CAS No.: 146954-74-7; 2'-Deoxy-5'-O-DMT-2'-fluorouridine. PROPERTIES: 2'-Deoxy-5'-O-DMT-2'-fluorouridine is a nucleoside analog used in oligonucleotide synthesis. This compound has a molecular weight of 429.31 g/mol and appears as a white to off-white solid. It exhibits limited water solubility but dissolves in common organic solvents. 2'-Deoxy-5'-O-DMT-2'-fluorouridine should be stored at -20 C in a tightly sealed, light-protected container. It is sensitive to moisture and light. Safety considerations include potential eye and skin irritation, so protective measures are advised. APPLICATIONS: 2'-Deoxy-5'-O-DMT-2'-fluorouridine is utilized as a monomer in the solid-phase synthesis of 2'-fluoro-modified DNA oligonucleotides. These modified oligonucleotides exhibit increased stability against nuclease degradation and enhanced binding affinity to complementary strands. In molecular biology, they are used as probes in hybridization assays. In therapeutic applications, 2'-Deoxy-5'-O-DMT-2'-fluorouridine contributes to the development of antisense drugs and PCR primers with improved performance. These applications are referenced in oligonucleotide chemistry literature and molecular biology research publications.
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