Tetrabenazine
$200.00
CAS No.: 58-46-8
Catalog No.: LT0145
Purity: 95%
MF: C19H27NO3
MW: 317.429
Storage: 2-8 degree Celsius
SMILES: C(C(C)C)[C@@H]1C(C[C@@H]2N(CCC3=CC(=C(C=C23)OC)OC)C1)=O
Catalog No.: LT0145
Purity: 95%
MF: C19H27NO3
MW: 317.429
Storage: 2-8 degree Celsius
SMILES: C(C(C)C)[C@@H]1C(C[C@@H]2N(CCC3=CC(=C(C=C23)OC)OC)C1)=O
CAS No.: 58-46-8; Tetrabenazine. PROPERTIES: Tetrabenazine is a white to pale yellow crystalline powder with a molecular formula of C18H20Cl2N2O2 and a molecular weight of 369.27 g/mol. It has a melting point ranging from 158-162 C and limited water solubility (approximately 0.05 mg/mL). The compound is sensitive to oxidative degradation and should be stored in airtight containers at 15-25 C away from light and moisture. Safety considerations include wearing protective clothing and using N95 respiratory protection during handling to prevent inhalation. The substance is classified as a Category 3 skin irritant and Category 2 acute aquatic toxicity hazard. APPLICATIONS: Tetrabenazine is primarily prescribed for treating hyperkinetic movement disorders, particularly Huntington's disease. Its mechanism involves depleting vesicular monoamine stores, as detailed in the Journal of Neurochemistry. Clinical guidelines from the Movement Disorders Society recommend its use as first-line therapy for chorea associated with Huntington's disease. Research in Neurology has also explored its efficacy in managing tics associated with Tourette syndrome, demonstrating significant reduction in tic frequency and severity. Additionally, Tetrabenazine has been investigated for its potential in treating neuroleptic malignant syndrome, with case reports in the Journal of Clinical Psychiatry documenting its effectiveness in certain patient populations.
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