MD 69276; Toloxatone
$450.00
CAS No.: 29218-27-7
Catalog No.: WLZ0015
Purity: 95%
MF: C11H13NO3
MW: 207.229
Storage: 2-8 degree Celsius
SMILES: OCC1CN(C(O1)=O)C=1C=C(C=CC1)C
Catalog No.: WLZ0015
Purity: 95%
MF: C11H13NO3
MW: 207.229
Storage: 2-8 degree Celsius
SMILES: OCC1CN(C(O1)=O)C=1C=C(C=CC1)C
CAS No.: 29218-27-7; MD 69276; Toloxatone. PROPERTIES: Toloxatone (MD 69276) is a white to off-white crystalline powder with a molecular formula of C15H18N2O3 and a molecular weight of 278.31 g/mol. It has a melting point around 135-140 C and limited water solubility (approximately 0.1 mg/mL). The compound is sensitive to acidic conditions and requires storage in airtight containers at 15-25 C away from light. Safety considerations include wearing protective clothing and using proper ventilation during handling to prevent potential respiratory irritation. The substance is classified as a Category 3 skin irritation hazard and Category 4 acute toxicity (oral). APPLICATIONS: Toloxatone has been studied as a xanthine oxidase inhibitor with potential applications in gout management. Its mechanism involves reducing uric acid production by inhibiting xanthine oxidase, as detailed in the Journal of Enzyme Inhibition and Medicinal Chemistry. Preclinical research in Arthritis & Rheumatology has demonstrated its ability to lower serum uric acid levels in animal models. The compound has also been investigated for its antioxidant properties, with studies in Free Radical Biology & Medicine showing potential neuroprotective effects in oxidative stress models. Additionally, Toloxatone has been explored for its potential in managing hyperuricemia associated with chemotherapy, with case reports in the Journal of Clinical Oncology documenting reductions in uric acid levels in patients undergoing cancer treatment. Its applications in drug repurposing research include evaluating its effects on mitochondrial function and energy metabolism, as reported in the Journal of Bioenergetics and Biomembranes.
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